Bachellier S, Perrin D, Hofnung M, Gilson E
Unité de Programmation Moléculaire et Toxicologie Génétique, CNRS URA 1444, Institut Pasteur, Paris, France.
Mol Microbiol. 1993 Feb;7(4):537-44. doi: 10.1111/j.1365-2958.1993.tb01144.x.
Bacterial interspersed mosaic elements (BIMEs) constitute a family of highly repetitive sequences containing palindromic units (PUs), also called repetitive extragenic palindromes (REPs). BIMEs were originally described in Escherichia coli and Salmonella typhimurium. We show here, by determining the nucleotide sequence of two intergenic regions of Klebsiella pneumoniae, by computer searches, and by hybridization, that sequences with similar characteristics are found in the genome of several Klebsiella species. This reinforces the idea that BIMEs play general and important roles in enterobacteria such as in the organization of the bacterial chromosome.
细菌散布镶嵌元件（BIMEs）构成了一个高度重复序列家族，其中包含回文单元（PUs），也称为重复基因外回文序列（REPs）。BIMEs最初是在大肠杆菌和鼠伤寒沙门氏菌中发现的。我们通过测定肺炎克雷伯菌两个基因间区域的核苷酸序列、计算机搜索以及杂交实验，发现几种克雷伯菌属的基因组中存在具有相似特征的序列。这进一步证实了BIMEs在肠杆菌中发挥着普遍且重要的作用，比如在细菌染色体的组织方面。
