ERIC序列：大肠杆菌、鼠伤寒沙门氏菌及其他肠道细菌基因组中的一类新型重复元件。

ERIC sequences: a novel family of repetitive elements in the genomes of Escherichia coli, Salmonella typhimurium and other enterobacteria.

作者信息

Hulton C S, Higgins C F, Sharp P M

机构信息

Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, UK.

出版信息

Mol Microbiol. 1991 Apr;5(4):825-34. doi: 10.1111/j.1365-2958.1991.tb00755.x.

DOI:10.1111/j.1365-2958.1991.tb00755.x

PMID:1713281

Abstract

We describe a family of highly conserved, Enterobacterial Repetitive Intergenic Consensus (ERIC) sequences, 14 of which have been identified in Escherichia coli and Salmonella typhimurium and a further three in other enterobacterial species (Yersinia pseudotuberculosis, Klebsiella pneumoniae and Vibrio cholerae). ERIC sequences are 126 bp long and appear to be restricted to transcribed regions of the genome, either in intergenic regions of polycistronic operons or in untranslated regions upstream or downstream of open reading frames. ERIC sequences are highly conserved at the nucleotide sequence level but their chromosomal locations differ between species. Several features of ERIC sequences resemble those of REP sequences (Stern et al., 1984) although the nucleotide sequence is entirely different. The question of whether ERICs have a specific function, or represent a form of 'selfish' DNA, is discussed.

摘要

我们描述了一个高度保守的肠杆菌重复基因间共有序列（ERIC）家族，其中14个已在大肠杆菌和鼠伤寒沙门氏菌中被鉴定出来，另外3个在其他肠杆菌物种（假结核耶尔森菌、肺炎克雷伯菌和霍乱弧菌）中被鉴定出来。ERIC序列长度为126 bp，似乎局限于基因组的转录区域，要么存在于多顺反子操纵子的基因间区域，要么存在于开放阅读框上游或下游的非翻译区域。ERIC序列在核苷酸序列水平上高度保守，但它们在不同物种中的染色体位置有所不同。尽管核苷酸序列完全不同，但ERIC序列的几个特征与REP序列（斯特恩等人，1984年）的特征相似。文中讨论了ERIC序列是否具有特定功能，或者是否代表一种“自私”DNA形式的问题。