Nunley D L, Perlman P E
Postgrad Med. 1993 Apr;93(5):235-8, 241-4, 247. doi: 10.1080/00325481.1993.11701672.
Infective endocarditis refers to infection of the endocardium or heart valves by microbes, resulting in tissue destruction. Clinical presentation is quite variable, and a high level of suspicion is essential for recognition. Diagnosis is dependent on identification of the causative agent in blood cultures. Cultures that are persistently negative indicate the presence of culture-negative endocarditis, and diagnosis is one of exclusion. Treatment of endocarditis consists of high doses of antibiotics active against the infecting organism. Individualized therapy is the key to management.
感染性心内膜炎是指微生物感染心内膜或心脏瓣膜，导致组织破坏。临床表现差异很大，高度怀疑对于识别至关重要。诊断取决于血培养中病原体的鉴定。持续阴性的培养结果提示存在血培养阴性的心内膜炎，诊断是排除性诊断之一。心内膜炎的治疗包括使用高剂量的对感染病原体有效的抗生素。个体化治疗是管理的关键。
