Bacharach J M, Stanson A W, Lie J T, Nichols D A
Cleveland Clinic Foundation, Ohio.
Radiographics. 1993 Mar;13(2):417-23. doi: 10.1148/radiographics.13.2.8460227.
The association of antiphospholipid antibodies with unexplained thrombo-occlusive vascular disease is well known but often remains unrecognized. The most well-studied clinical manifestation is venous thrombosis, but arterial occlusive disease involving multiple sites is also well documented. Twenty-six cases of thrombo-occlusive disease were observed in 22 patients over a 3-year period. Magnetic resonance imaging and angiography were used to make the diagnoses. None of the patients who underwent angiography or venography developed thrombolytic disease related to the puncture site. This group of patients with antiphospholipid antibody syndrome had a wide distribution of arterial and venous thrombotic disease. Radiologists should consider antiphospholipid antibody syndrome in the differential diagnosis when evaluating thrombo-occlusive vascular disease that is unexpected or occurs without risk factors. Knowledge of antiphospholipid antibody status has important implications for prognosis and therapy.
抗磷脂抗体与不明原因的血栓闭塞性血管疾病之间的关联已广为人知，但往往仍未被识别。研究最多的临床表现是静脉血栓形成，但累及多个部位的动脉闭塞性疾病也有充分的文献记载。在3年期间，22例患者中观察到26例血栓闭塞性疾病。使用磁共振成像和血管造影进行诊断。接受血管造影或静脉造影的患者中，没有一人发生与穿刺部位相关的溶栓疾病。这组抗磷脂抗体综合征患者的动脉和静脉血栓性疾病分布广泛。放射科医生在评估意外发生或无危险因素的血栓闭塞性血管疾病时，应在鉴别诊断中考虑抗磷脂抗体综合征。了解抗磷脂抗体状态对预后和治疗具有重要意义。
