Skipsey I G, Colvin J R, Mackenzie N, Kenny G N
Department of Anaesthesia, Ninewells Hospital and Medical School, Dundee.
Anaesthesia. 1993 Mar;48(3):210-3. doi: 10.1111/j.1365-2044.1993.tb06903.x.
The ability of a target-controlled propofol infusion system to provide sedation for 40 patients undergoing surgery under regional blockade was assessed. Eighty-eight per cent of the total infusion time was at the desired sedation level with little oversedation. This was achieved with a median blood propofol concentration of 0.93 micrograms.ml-1. The pharmacokinetic algorithm performed as well when used for sedation as for total intravenous anaesthesia. The predicted and measured blood propofol concentrations showed a bias of -12% and a precision of 34%.
评估了靶控丙泊酚输注系统为40例接受区域阻滞手术患者提供镇静的能力。在总输注时间的88%内，患者处于所需镇静水平，很少出现过度镇静。实现这一目标时，丙泊酚血药浓度中位数为0.93微克·毫升⁻¹。该药代动力学算法用于镇静时与用于全静脉麻醉时表现相同。预测的和实测的丙泊酚血药浓度偏差为-12%，精密度为34%。
