Diz P, Ocampo A, Miralles C, Otero I, Iglesias I, Martínez C
Facultad de Medicina y Odontología, Universidad de Santiago de Compostela, La Coruña.
Enferm Infecc Microbiol Clin. 1993 Jan;11(1):36-9.
Fluconazole-resistant Candida albicans has been seldom reported in the literature. in this study, two clinical cases of oro-esophageal candidosis resistant to this antifungal drug are described.
Infection was confirmed by isolation of yeasts (culture of mouth swabs, oesophagoscopy and histology of biopsy specimens). In vitro antifungal susceptibility tests were performed with standard methods (NCCLS).
Clinical and microbiological fluconazole-resistant Candida albicans was isolated.
Causes of development of resistances are commented, and the role of immunodeficiency and the possibility of a Candida strain selection is discussed.
文献中很少报道对氟康唑耐药的白色念珠菌。本研究描述了两例对这种抗真菌药物耐药的口腔-食管念珠菌病临床病例。
通过分离酵母（口腔拭子培养、食管镜检查和活检标本组织学检查）确诊感染。采用标准方法（美国国家临床实验室标准化委员会）进行体外抗真菌药敏试验。
分离出临床和微生物学上对氟康唑耐药的白色念珠菌。
对耐药性产生的原因进行了评论，并讨论了免疫缺陷的作用以及念珠菌菌株选择的可能性。
