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The development of vitamin D3 analogues for the treatment of osteoporosis.

作者信息

Nishii Y, Sato K, Kobayashi T

机构信息

Bone and Calcified Tissue Research Laboratory, Chugai Pharmaceutical Co, Tokyo, Japan.

出版信息

Osteoporos Int. 1993;3 Suppl 1:190-3. doi: 10.1007/BF01621903.

DOI:10.1007/BF01621903
PMID:8461556
Abstract
摘要

相似文献

1
The development of vitamin D3 analogues for the treatment of osteoporosis.
Osteoporos Int. 1993;3 Suppl 1:190-3. doi: 10.1007/BF01621903.
2
A new active vitamin D analog, ED-71, causes increase in bone mass with preferential effects on bone in osteoporotic patients.一种新型活性维生素D类似物ED-71可增加骨质疏松症患者的骨量，并对骨骼产生优先作用。
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[Vitamin-D analogues for osteoporosis].[用于骨质疏松症的维生素D类似物]
Clin Calcium. 2006 Jul;16(7):1208-11.
4
ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis.在雌激素缺乏的骨质疏松大鼠模型中，维生素D类似物ED-71比阿法骨化醇更有效地抑制骨吸收。
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Prevention and management of osteoporosis: consensus statements from the Scientific Advisory Board of the Osteoporosis Society of Canada. 8. Vitamin D metabolites and analogs in the treatment of osteoporosis.骨质疏松症的预防与管理：加拿大骨质疏松症协会科学咨询委员会的共识声明。8. 维生素D代谢物及类似物在骨质疏松症治疗中的应用
CMAJ. 1996 Oct 1;155(7):955-61.
6
Supplementation with oral vitamin D3 and calcium during winter prevents seasonal bone loss: a randomized controlled open-label prospective trial.冬季补充口服维生素D3和钙可预防季节性骨质流失：一项随机对照开放标签前瞻性试验。
J Bone Miner Res. 2004 Aug;19(8):1221-30. doi: 10.1359/JBMR.040511. Epub 2004 May 24.
7
Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone.每日给予活性维生素 D 类似物艾地骨化醇（ED-71）可通过抑制小鼠小梁骨中 RANKL 的表达来增加骨密度。
J Bone Miner Res. 2012 Feb;27(2):461-73. doi: 10.1002/jbmr.555.
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Eldecalcitol and calcitriol stimulates 'bone minimodeling,' focal bone formation without prior bone resorption, in rat trabecular bone.艾地骨化醇和骨化三醇刺激“骨微模型”，在大鼠小梁骨中形成无预先骨吸收的焦点骨形成。
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[New bone density conservation agents for osteoporosis under research and development: ED-71].[正在研发的用于骨质疏松症的新型骨密度保护剂：依替膦酸二钠（ED-71）]
Nihon Rinsho. 2007 Nov 28;65 Suppl 9:454-8.
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Rationale for active vitamin D and analogs in the treatment of osteoporosis.活性维生素D及其类似物治疗骨质疏松症的理论依据。
J Cell Biochem. 2003 Feb 1;88(2):381-6. doi: 10.1002/jcb.10328.

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Update on pharmacologically-relevant vitamin D analogues.关于具有药理相关性的维生素 D 类似物的最新进展。
Br J Clin Pharmacol. 2019 Jun;85(6):1095-1102. doi: 10.1111/bcp.13781. Epub 2018 Nov 22.
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Vitamin D metabolism, mechanism of action, and clinical applications.维生素D的代谢、作用机制及临床应用。
Chem Biol. 2014 Mar 20;21(3):319-29. doi: 10.1016/j.chembiol.2013.12.016. Epub 2014 Feb 13.
3
Superiority of alfacalcidol compared to vitamin D plus calcium in lumbar bone mineral density in postmenopausal osteoporosis.

本文引用的文献

1
Comparison of the effects of vitamin D metabolites on collagen synthesis and resportion of fetal rat bone in organ culture.维生素D代谢产物对器官培养中胎鼠骨骼胶原蛋白合成与分解的影响比较。
Calcif Tissue Int. 1980;32(2):135-8. doi: 10.1007/BF02408532.
2
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture.1,25-二羟胆钙化醇：组织培养中骨吸收的强效刺激剂。
Science. 1972 Feb 18;175(4023):768-9. doi: 10.1126/science.175.4023.768.
3
Circulating 1 alpha,25-dihydroxyvitamin D levels after a single dose of 1 alpha,25-dihydroxyvitamin D3 or 1 alpha-hydroxyvitamin D3 in normal men.
在绝经后骨质疏松症患者中，阿法骨化醇在增加腰椎骨密度方面优于维生素D加钙。
Rheumatol Int. 2006 Mar;26(5):445-53. doi: 10.1007/s00296-005-0073-4. Epub 2005 Nov 10.
4
1,25-Dihydroxyvitamin D3 in the pathogenesis and treatment of osteoporosis.1,25-二羟维生素D3在骨质疏松症的发病机制及治疗中的作用
Osteoporos Int. 1997;7 Suppl 3:S24-9. doi: 10.1007/BF03194338.
正常男性单次服用1α,25 - 二羟基维生素D3或1α - 羟基维生素D3后循环血中1α,25 - 二羟基维生素D的水平
Bone Miner. 1987 Sep;2(6):479-85.
4
Regulatory activities of 2 beta-(3-hydroxypropoxy)-1 alpha, 25-dihydroxyvitamin D3, a novel synthetic vitamin D3 derivative, on calcium metabolism.
Biochem Biophys Res Commun. 1989 Sep 29;163(3):1444-9. doi: 10.1016/0006-291x(89)91140-6.
5
Metabolic effects of synthetic calcitriol (Rocaltrol) in the treatment of postmenopausal osteoporosis.合成骨化三醇（罗钙全）治疗绝经后骨质疏松症的代谢效应
Metabolism. 1990 Apr;39(4 Suppl 1):27-9. doi: 10.1016/0026-0495(90)90268-h.
6
Metabolism of 1alpha-hydroxyvitamin D3 to 1alpha, 25-dihydroxyvitamin D3 in perfused rat liver.灌注大鼠肝脏中1α-羟基维生素D3向1α,25-二羟基维生素D3的代谢
Biochem Biophys Res Commun. 1975 Sep 16;66(2):632-8. doi: 10.1016/0006-291x(75)90556-2.
7
A specific high-affinity binding macromolecule for 1,25-dihydroxyvitamin D3 in fetal bone.
Science. 1977 Sep 9;197(4308):1086-8. doi: 10.1126/science.887939.
8
Highly specific binding of 1,25-dihydroxycholecalciferol in bone cytosol.1,25 - 二羟胆钙化醇在骨细胞溶质中的高度特异性结合。
J Endocrinol. 1979 Jan;80(1):35-9. doi: 10.1677/joe.0.0800035.