Schmidt D, Vogel A
Klin Wochenschr. 1977 Mar 1;55(5):219-23. doi: 10.1007/BF01487714.
Intravenous injection of 3 mg/kg phenytoin produced plasma concentrations of 4.2 mug/ml in five volunteers, which were below the concentration of 10-20 mjg/ml necessary for effective antiarrhythmic and antiepileptic treatment. Intravenous injection of 250 mg phenytoin followed by infusion of 750 mg phenytoin in a mean dosage of 1.7 mg/kg x h in nine patients with epilepsy produced plasma concentrations of 10.2 resp. 15.1 mug/ml after 4 resp. 8h. An oral maintenance therapy of 5-6 mg/kg is suggested. Therapeutic plasma concentrations were rapidly reached with this regimen.
静脉注射3毫克/千克苯妥英钠后，五名志愿者的血浆浓度为4.2微克/毫升，低于有效抗心律失常和抗癫痫治疗所需的10 - 20微克/毫升的浓度。对九名癫痫患者静脉注射250毫克苯妥英钠，随后以平均剂量1.7毫克/千克×小时输注750毫克苯妥英钠，4小时和8小时后的血浆浓度分别为10.2微克/毫升和15.1微克/毫升。建议口服维持治疗剂量为5 - 6毫克/千克。采用该治疗方案可迅速达到治疗性血浆浓度。
