Kramer P, Langescheid C, Saul J, Heuer E, Löffler G, Köthe E, McIntosh C, Scheler F
Klin Wochenschr. 1977 Mar 1;55(5):245-6. doi: 10.1007/BF01487719.
Plasma digoxin suspected to be elevated in anuric patients taking digitoxin was determined by radioimmunoassay in 15 anuric patients and 15 normal persons subjected to 0.1 mg digitoxin therapy per day. All plasma digoxin values from the anuric patients and the normal subjects were far below the lower limit of the therapeutic range of plasma digoxin. There existed no difference between the digoxin values determined in anuric patients and subjects with normal renal function; in both groups there was a scatter of digoxin values about the cross reaction line between digitoxin and digoxin antibody. It is concluded from the results that digoxin retention in anuric patients taking digitoxin plays an insignificant role; thus, the pharmacological effect is mediated by digitoxin itself.
通过放射免疫分析法测定了15名无尿患者和15名每天接受0.1mg洋地黄毒苷治疗的正常人的血浆地高辛水平，这些无尿患者服用洋地黄毒苷后血浆地高辛疑似升高。所有无尿患者和正常受试者的血浆地高辛值均远低于血浆地高辛治疗范围的下限。无尿患者和肾功能正常受试者测定的地高辛值之间没有差异；两组中地高辛值在地高辛和地高辛抗体之间的交叉反应线周围均有离散。从结果得出结论，服用洋地黄毒苷的无尿患者中地高辛潴留起的作用不显著；因此，药理作用是由洋地黄毒苷本身介导的。
