Szefler S J, Koup J R, Giacoia G P
J Pediatr. 1977 Sep;91(3):487-9. doi: 10.1016/s0022-3476(77)81331-0.
Serum digoxin values were determined in a newborn infant with severe heart failure and renal failure. The half-life of digoxin in the serum appeared to change, possibly the result of prolonged distribution and/or absorption owing to circulatory insufficiency, or to the accumulation of cross-reacting metabolites of digoxin in the serum. No clinical toxicity was apparent, and no cardiac arrhythmia was observed. The need for monitoring serum digoxin concentration and clinical effect in newborn infants is emphasized.
对一名患有严重心力衰竭和肾衰竭的新生儿测定了血清地高辛值。血清地高辛的半衰期似乎发生了变化，这可能是由于循环功能不全导致分布和/或吸收时间延长，或者是血清中地高辛交叉反应代谢产物蓄积的结果。未出现明显的临床毒性，也未观察到心律失常。强调了监测新生儿血清地高辛浓度和临床效果的必要性。
