Müller G, Kieninger G, Breucha G, Voigt H, Schmidt K
Langenbecks Arch Chir. 1977 Feb 12;343(3):243-50. doi: 10.1007/BF01267995.
Five female mini-pigs underwent total colectomy including resection of the ileocecal valve. Sparing the terminal rectum, we reformed an end-to-end anastomosis between terminal ileum and remaining rectal cuff. In a second series 8 female mini-pigs have been colectomized using the same model. To delay intestinal passage, in addition a 10-12 cm long reversed segment of terminal ileum has been inserted between small bowel and rectal stump. Both groups were compared with a group of normal unoperated mini-pigs in a study up to 1 year, observing intestinal transit time, blood chemistry and general development of the animals. It could be proved that the reversal of a small bowel segment in colectomized animals leads to a prolongation of the intestinal transit time, to normalization of electrolytes and general appearance. Colectomy was only survived by animals with a reversed segment. The clinical application of a reversed small bowel segment following total colectomy in 1 patient was successful.
五只雌性小型猪接受了包括回盲瓣切除在内的全结肠切除术。保留终末直肠，我们在终末回肠和剩余直肠残端之间进行了端端吻合。在第二个系列中，8只雌性小型猪使用相同模型进行了结肠切除术。为了延迟肠道通过，另外在小肠和直肠残端之间插入了一段10 - 12厘米长的终末回肠反转段。在长达1年的研究中，将这两组与一组未手术的正常小型猪进行比较，观察动物的肠道转运时间、血液化学指标和总体发育情况。可以证明，结肠切除动物的小肠段反转会导致肠道转运时间延长、电解质正常化和总体外观正常。只有有反转段的动物在结肠切除术后存活下来。1例患者在全结肠切除术后应用反转小肠段的临床应用取得成功。
