Bung P, Stein C, Prinz R, Pietrzik K, Schlebusch H, Bauer O, Krebs D
Universitätsfrauenklinik Bonn.
Geburtshilfe Frauenheilkd. 1993 Feb;53(2):92-9. doi: 10.1055/s-2007-1023644.
After discussing the problem of folic acid requirements and supply during pregnancy, the results of a longitudinal study on 162 pregnant women are presented. By measuring biochemical and morphological changes in two subgroups (non-substituted vs unspecifically substituted), the necessity of a substitution with folic acid is discussed, as there might be additional requirements for the pregnant and the foetal organism. Concentrations of folic acid in the maternal plasma and in the erythrocytes as well as the segmentation rate and hypersegmentation of the granulocytes show a clear decrease in pregnancy. At the same time there was a significant difference between the subjects substituted and not substituted; the foetus and newborn levels were much higher than their mothers' concentrations. Moreover, there was a correlation between red cells folic acid levels in the last trimester and duration and outcome of pregnancy. These results indicate a substitution with folic acid for certain populations in pregnancy, which are highlighted.
在讨论了孕期叶酸需求和供应问题之后，本文呈现了一项针对162名孕妇的纵向研究结果。通过测量两个亚组（未补充叶酸组与非特异性补充叶酸组）的生化和形态学变化，探讨了补充叶酸的必要性，因为孕妇和胎儿机体可能有额外的需求。孕妇血浆和红细胞中的叶酸浓度以及粒细胞的分叶率和超分叶现象在孕期均明显下降。同时，补充叶酸组与未补充叶酸组之间存在显著差异；胎儿和新生儿的叶酸水平远高于其母亲的浓度。此外，孕晚期红细胞叶酸水平与孕期时长及妊娠结局之间存在相关性。这些结果表明，孕期某些特定人群需要补充叶酸，文中对此进行了重点强调。
