Weil A, Mauracher E
Schweiz Med Wochenschr. 1977 Dec 31;107(52):1943-7.
The efficacy of prophylactic treatment with ferrous sulfate (80 mg Fe++) and the combination of ferrous sulfate with folic acid (80 mg Fe++ and 350 microgram folic acid) were studied in a double blind trial in the 20th, and again in the 30th and 36th week of pregnancy (29 patients). At the beginning of the treatment (20th week) 29% of the patients showed a pathologically reduced serum folic acid level. Combined therapy has a favorable effect on the folic acid levels in the serum and red blood cells; this was confirmed statistically. At the end of pregnancy, 69% of the patients of the control group (ferrous sulfate) showed a pathologically reduced serum level and 23% a subnormal level in erythrocytes. These results unquestionably justify the prophylactic prescription of folic acid during pregnancy.
在一项针对29名孕妇的双盲试验中，研究了硫酸亚铁（80毫克亚铁离子）以及硫酸亚铁与叶酸联合使用（80毫克亚铁离子和350微克叶酸）进行预防性治疗的效果，试验分别在妊娠第20周、第30周和第36周进行。治疗开始时（第20周），29%的患者血清叶酸水平病理性降低。联合治疗对血清和红细胞中的叶酸水平有良好影响；这一点得到了统计学证实。妊娠结束时，对照组（硫酸亚铁）69%的患者血清水平病理性降低，23%的患者红细胞水平低于正常。这些结果无疑证明了孕期预防性补充叶酸的合理性。
