Morin R J, Davidson W D, Rorke S J, Guo L S
Lipids. 1977 Feb;12(2):208-14. doi: 10.1007/BF02533296.
Plasma, liver, and adipose tissue lipid composition and synthesis from [1-14C] acetate were studied three months following induction of nephrotic syndrome in rats by injection of antiglomerular basement membrane protein. Plasma triglyceride concentrations and specific radioactivities were elevated, and the triglycerides contained increased proportions of oleic acid. Plasma cholesterol and phospholipid concentrations were also increased, but free fatty acid levels were not. Liver triglyceride concentrations were decreased and incorporation of [1-14] acetate into liver triglycerides was also depressed below that of normal controls. Nephrotic rat liver triglycerides contained a higher proportion of oleic acid and lower arachidonic acid than did controls. Incorporation of [1-14C] acetate into adipose tissue lipids of the nephrotic rats was increased, and the proportion of palmitic acid was decreased. In the chronic nephrotic rat, the major source of the increased plasma triglycerudes may be fatty acids mobilized from adipose tissue stores.
通过注射抗肾小球基底膜蛋白诱导大鼠肾病综合征三个月后，研究了血浆、肝脏和脂肪组织的脂质组成以及[1-14C]乙酸盐的合成情况。血浆甘油三酯浓度和比放射性升高，且甘油三酯中油酸比例增加。血浆胆固醇和磷脂浓度也升高，但游离脂肪酸水平未升高。肝脏甘油三酯浓度降低，[1-14C]乙酸盐掺入肝脏甘油三酯的量也低于正常对照组。肾病大鼠肝脏甘油三酯中油酸比例高于对照组，花生四烯酸比例低于对照组。[1-14C]乙酸盐掺入肾病大鼠脂肪组织脂质的量增加，棕榈酸比例降低。在慢性肾病大鼠中，血浆甘油三酯增加的主要来源可能是从脂肪组织储存中动员出来的脂肪酸。
