Almegård B, Andersson S E
Department of Physiology and Medical Biophysics, Uppsala University, Sweden.
J Ocul Pharmacol. 1993 Spring;9(1):77-84. doi: 10.1089/jop.1993.9.77.
The effects of cholecystokinin (CCK) and calcitonin gene-related peptide (CGRP) on ocular blood flow were studied in monkeys using the labelled microsphere method. Intracameral administration of 800 pmole CGRP increased the blood flow significantly in the conjunctiva, ciliary body and sclera. There was no significant change in the choroid and retina. CCK-33 (800 pmole) caused no significant effects on the blood flow in the tissues examined, when compared to the control eyes. A miotic response was however noted, consistent with previous results. Neither peptide caused significant changes in the intraocular pressure. These results suggest that CGRP has a vasodilatory effect in some parts of the monkey eye, whereas CCK-33 is a miotic with no marked effect on ocular blood flow.
采用标记微球法在猴子身上研究了胆囊收缩素（CCK）和降钙素基因相关肽（CGRP）对眼血流量的影响。前房内注射800皮摩尔CGRP可使结膜、睫状体和巩膜的血流量显著增加。脉络膜和视网膜无明显变化。与对照眼相比，CCK - 33（800皮摩尔）对所检查组织的血流量无显著影响。然而，观察到了缩瞳反应，这与之前的结果一致。两种肽均未引起眼压的显著变化。这些结果表明，CGRP在猴眼的某些部位具有血管舒张作用，而CCK - 33是一种缩瞳剂，对眼血流量无明显影响。
