Misra L N, Ahmad A, Thakur R S, Lotter H, Wagner H
Central Institute of Medicinal and Aromatic Plants, Lucknow, India.
J Nat Prod. 1993 Feb;56(2):215-9. doi: 10.1021/np50092a005.
Artemisinic acid [1], a possible biogenetic precursor of the antimalarial artemisinin [2], was isolated from the hexane extract of Artemisia annua. X-ray crystallography of the dimer of artemisinic acid shows that the cyclization during intermolecular hydrogen bonding occurs by the opposite orientation of the alpha, beta-methylene group in each molecule. Complete spectroscopic data of 1 are also given.
青蒿酸[1]是抗疟药物青蒿素[2]可能的生物合成前体，它是从黄花蒿的正己烷提取物中分离得到的。青蒿酸二聚体的X射线晶体学研究表明，分子间氢键形成过程中的环化反应是通过每个分子中α,β-亚甲基基团的相反取向发生的。文中还给出了化合物1的完整光谱数据。
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