Bellamy F, Horton D, Millet J, Picart F, Samreth S, Chazan J B
Laboratoires Fournier S.A., Centre de Recherche, Daix, France.
J Med Chem. 1993 Apr 2;36(7):898-903. doi: 10.1021/jm00059a015.
A series of glycosylated derivatives of benzophenone, benzhydrol, and benzhydril has been synthesized and evaluated for potential activity as venous antithrombotic agents. Studies on structure-activity relationships revealed that compounds having an electron-withdrawing group in the benzhydril or benzhydrol moiety, and specifically those having the beta-D-xylopyranosyl structure in the sugar moiety, were good antithrombotic agents in a rat model of venous thrombosis.
已合成了一系列二苯甲酮、二苯甲醇和二苯甲基的糖基化衍生物，并对其作为静脉抗血栓形成剂的潜在活性进行了评估。构效关系研究表明，在二苯甲基或二苯甲醇部分具有吸电子基团的化合物，特别是在糖部分具有β-D-吡喃木糖基结构的那些化合物，在大鼠静脉血栓形成模型中是良好的抗血栓形成剂。
