Kan T, Mitomi H, Saigenji K, Atari E
Department of Internal Medicine, Kitasato University School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 1993 Feb;90(2):114-23.
The effect of PGE1 and PGF2 alpha in the ischemic intestinal tract were examined. In 40 mongrel dogs, we studied ischemic models of small intestine. PGE1 or PGF2 alpha was injected into the anterior mesenteric artery after reperfusion according to each occlusion time, and the tissue blood flow was measured on both mucosal and serous sides of small intestinal loop by laser flowmeter to examine the relation to the extent of tissue damage. Tissue blood flow of the ischemic intestine after the injection of PGE1 increased by 148-208% in the 3-5 hr occlusion group and by 86-110% in the 7-10 hr occlusion group. Tissue blood flow after the injection of PGF2 alpha decreased by 39-59% in the 3-5 hr occlusion group and by 1-15% in the 7-10 hr occlusion group. These results indicate that the effect of PGE1 and PGF2 alpha in the ischemic intestine would be available up to 3-5 hr of ischemia. Histological examination revealed that viability of the remaining crypt was high in the PGE1 injection group but low in the PGF2 alpha injection group. These findings suggest that PGE1, if try at the early stage, would be effective for the treatment of ischemic lesion.
研究了前列腺素E1（PGE1）和前列腺素F2α（PGF2α）对缺血肠道的作用。在40只杂种犬中，我们研究了小肠缺血模型。根据不同的阻断时间，在再灌注后将PGE1或PGF2α注入肠系膜前动脉，并用激光流量计测量小肠肠袢黏膜侧和浆膜侧的组织血流量，以研究其与组织损伤程度的关系。在3 - 5小时阻断组中，注射PGE1后缺血肠道的组织血流量增加了148 - 208%，在7 - 10小时阻断组中增加了86 - 110%。在3 - 5小时阻断组中，注射PGF2α后组织血流量减少了39 - 59%，在7 - 10小时阻断组中减少了1 - 15%。这些结果表明，PGE1和PGF2α对缺血肠道的作用在缺血3 - 5小时内是有效的。组织学检查显示，PGE1注射组中剩余隐窝的活力较高，而PGF2α注射组中则较低。这些发现表明，如果在早期尝试使用PGE1，对缺血性病变的治疗可能有效。
