Ohkuma M
Department of Dermatology, Kinki University, School of Medicine, Osaka-Sayama, Japan.
Lymphology. 1993 Mar;26(1):38-41.
Lipoperoxide has been detected in the thoracic duct lymph of the dog. This finding suggests that lipoperoxides are normally transported in lymph and with impaired lymph drainage may be deposited in the skin and contribute to the soft tissue changes characteristic of chronic lymphedema. Accordingly, after obtaining skin specimens taken from 8 patients (7 with obstructive lymphedema) with lower extremity lymph stasis we determined dermal malondialdehyde (MDA) content (after conversion to fluorescent thiobarbituric acid or TBA), a marker of lipoperoxide. In all 7 patients with obstructive lymphedema, the MDA levels were increased compared to control dermis (p < 0.05). We suggest that inability to clear lipoperoxides from the dermis with lymphatic insufficiency may contribute to the pathogenesis and structural skin derangements of chronic lymphedema.
已在犬的胸导管淋巴液中检测到脂质过氧化物。这一发现表明，脂质过氧化物通常通过淋巴进行运输，并且在淋巴引流受损时可能会沉积在皮肤中，进而导致慢性淋巴水肿特有的软组织变化。因此，在获取了8例下肢淋巴淤积患者（7例为阻塞性淋巴水肿）的皮肤标本后，我们测定了皮肤中丙二醛（MDA）的含量（转化为荧光硫代巴比妥酸或TBA后），MDA是脂质过氧化物的一个标志物。在所有7例阻塞性淋巴水肿患者中，与对照皮肤相比，MDA水平均有所升高（p < 0.05）。我们认为，淋巴功能不全导致无法从真皮中清除脂质过氧化物，这可能会促使慢性淋巴水肿的发病机制及皮肤结构紊乱的发生。
