Ohkuma M
Department of Dermatology, Kinki University School of Medicine, Osaka, Japan.
Lymphology. 1989 Sep;22(3):150-2.
Lipoperoxide levels were examined in thoracic duct lymph (TDL) of 11 dogs. In four dogs with sodium citrate added in vitro to prevent coagulation, TDL had notably higher levels than in serum. After centrifugation, however, lymph supernatant levels of lipoperoxide closely approximated that in serum suggesting that the bulk of lipoperoxide remained in the sediment and derived from circulating cells. Interstitial accumulation of lipoperoxide, a breakdown product of cell membranes, may be a potent "toxic factor" responsible for trophic changes associated with chronic lymph-edema.
检测了11只狗胸导管淋巴液（TDL）中的脂过氧化物水平。在4只体外添加柠檬酸钠以防止凝血的狗中，TDL中的脂过氧化物水平显著高于血清中的水平。然而，离心后，淋巴上清液中的脂过氧化物水平与血清中的水平非常接近，这表明大部分脂过氧化物留在沉淀物中，并来源于循环细胞。脂过氧化物是细胞膜的分解产物，其在组织间隙的蓄积可能是导致慢性淋巴水肿相关营养改变的一种强效“毒性因子”。
