Lack of bupivacaine kinetic changes induced by flumazenil in mice.
作者信息
Bruguerolle B, Lorec A M
机构信息
Medical Pharmacology Laboratory, Faculty of Medicine of Marseille, France.
出版信息
Life Sci. 1993;52(17):PL165-7. doi: 10.1016/0024-3205(93)90073-c.
PMID:8464340
Abstract
This study was designed to document possible changes in bupivacaine kinetics in mice after a single 1 mg/kg injection of flumazenil. After a single 20 mg/kg i.p. dose of bupivacaine, C max, Vd, Cl and AUC were not significantly modified by flumazenil; even if T max was shown to be significantly shorter when flumazenil was associated, bupivacaine bioavailability did not seem to be modified and thus may not be involved in the explanation of previously reported increasing bupivacaine-induced mortality by flumazenil.
摘要
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