Baybutt R C, Smith J E, Yeh Y Y
Nutrition Department, Pennsylvania State University, University Park 16802.
Lipids. 1993 Mar;28(3):167-72. doi: 10.1007/BF02536635.
The purpose of this study was to determine the responsiveness of alveolar type II cells to dietary fish oil and the consequent effects on alveolar and lung surfactant. Rats were fed a corn oil or a fish oil diet for four weeks. Dietary n-3 fatty acids were readily incorporated into the type II cell phospholipids as indicated by higher levels of eicosapentaenoic acid (2.77 +/- 0.10%) and docosahexaenoic acid (1.63 +/- 0.10%) in the group receiving the fish oil diet. The elevated levels of n-3 fatty acids were accompanied by concomitant reduction in arachidonic acid and linoleic acid. Neither eicosapentaenoic acid nor docosahexaenoic acid was incorporated into type II cell triacylglycerols. Feeding a fish oil containing diet increased surfactant phospholipids, particularly 1,2-disaturated acyl phosphatidylcholines in whole lung compared to a corn oil diet. However, the amount of surfactant found in the alveolus was not different between the two diet treatment groups. The results suggest that dietary n-3 fatty acids stimulate synthesis and/or inhibit degradation of lung surfactant without altering surfactant secretion in alveoli.
本研究的目的是确定Ⅱ型肺泡细胞对膳食鱼油的反应性以及由此对肺泡和肺表面活性物质产生的影响。将大鼠分别用玉米油或鱼油饲料喂养四周。如接受鱼油饲料组中二十碳五烯酸（2.77±0.10%）和二十二碳六烯酸（1.63±0.10%）水平较高所示，膳食中的n-3脂肪酸很容易掺入Ⅱ型细胞磷脂中。n-3脂肪酸水平升高伴随着花生四烯酸和亚油酸的相应减少。二十碳五烯酸和二十二碳六烯酸均未掺入Ⅱ型细胞三酰甘油中。与玉米油饲料相比，喂养含鱼油的饲料可增加肺表面活性物质磷脂，尤其是全肺中的1,2-二饱和酰基磷脂酰胆碱。然而，两个饲料处理组在肺泡中发现的表面活性物质数量并无差异。结果表明，膳食中的n-3脂肪酸可刺激肺表面活性物质的合成和/或抑制其降解，而不会改变肺泡中表面活性物质的分泌。
