Kamata T
Second Department of Surgery, Kanazawa University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1993 Feb;94(2):104-13.
The effects of duodenogastric reflex on the development of residual stomach cancer and cell proliferation kinetics were investigated in Wistar rats. Billroth II resection (B-II group) was performed on 24 rats and Billroth I resection (B-I group) was performed on 22 rats. The incidence of cancer in the B-II group was 20.8%, though no cancer was noted in the B-I group. The incidences of the pseudopyloric gland, dilated gland and gastritis cystica profunda in the B-II group were significantly higher than those in the B-I group. The degree of mucosal atrophy was greater in the B-II group than in the B-I group. The stomal area in the B-II group had expansion of proliferative zone as well as increased S-phase duration and turn over time, compared with those in the B-I group. The sequence of histological and proliferative events associated with duodenogastric reflux suggests that the residual stomach in the B-II group is susceptible to the development of cancer.
在Wistar大鼠中研究了十二指肠-胃反流对残胃癌发生及细胞增殖动力学的影响。对24只大鼠施行毕Ⅱ式切除术（B-II组），对22只大鼠施行毕Ⅰ式切除术（B-I组）。B-II组的癌症发生率为20.8%，而B-I组未发现癌症。B-II组假幽门腺、扩张腺和深部囊肿性胃炎的发生率显著高于B-I组。B-II组黏膜萎缩程度大于B-I组。与B-I组相比，B-II组吻合口区增殖带扩大，S期持续时间和周转时间增加。与十二指肠-胃反流相关的组织学和增殖事件序列表明，B-II组的残胃易发生癌变。
