果蝇转录因子IID的最大亚基指导包含TBP和一种共激活因子的复合物的组装。
Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator.
作者信息
Weinzierl R O, Dynlacht B D, Tjian R
机构信息
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.
出版信息
Nature. 1993 Apr 8;362(6420):511-7. doi: 10.1038/362511a0.
The TFIID complex consists of the TATA-binding protein (TBP) and associated factors (TAFs) serving to mediate transcriptional activation by promoter-specific regulators. Here we report the cloning of Drosophila TAFII250 and the assembly of a partial complex containing recombinant TBP, TAFII110 and the C-terminal domain of TAFII250. This triple complex supports Sp1 activation and reveals specific interactions between TAFII250, TBP and TAFII110.
TFIID复合物由TATA结合蛋白（TBP）和相关因子（TAFs）组成，这些因子用于介导启动子特异性调节因子的转录激活。在此，我们报告果蝇TAFII250的克隆以及包含重组TBP、TAFII110和TAFII250 C末端结构域的部分复合物的组装。这种三元复合物支持Sp1激活，并揭示了TAFII250、TBP和TAFII110之间的特异性相互作用。
Zotero 插件