Swedo S E, Leonard H L, Schapiro M B, Casey B J, Mannheim G B, Lenane M C, Rettew D C
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD.
Pediatrics. 1993 Apr;91(4):706-13.
Eleven children with Sydenham's chorea (8 girls and 3 boys, mean age = 8.4 +/- 2.2 [SD] years) underwent comprehensive physical, neuropsychologic, and psychiatric examination. The chorea was manifested as dysarthria, gait disturbances, and frequent adventitious movements of the face, neck, trunk, and extremities. Antineuronal antibodies were present in 10 of 11 children. All children exhibited concomitant psychologic dysfunction, specifically obsessive-compulsive symptomatology, increased emotional lability, motoric hyperactivity, irritability, distractibility, and age-regressed behavior. Obsessive-compulsive symptoms were observed in 9 (82%) children, 4 of whom met diagnostic criteria for obsessive-compulsive disorder. These behavioral symptoms began several days to weeks before the chorea was observed, and they waxed and waned in severity along with the motoric abnormalities. These results suggest that psychologic, particularly obsessive-compulsive, symptoms are accompanying manifestations of Sydenham's chorea which may require medical attention.
11名患有 Sydenham 舞蹈病的儿童（8名女孩和3名男孩，平均年龄 = 8.4 ± 2.2 [标准差] 岁）接受了全面的身体、神经心理学和精神检查。舞蹈病表现为构音障碍、步态障碍以及面部、颈部、躯干和四肢频繁出现的不自主运动。11名儿童中有10名存在抗神经元抗体。所有儿童均伴有心理功能障碍，特别是强迫症状、情绪易激惹性增加、多动、易怒、注意力分散和行为退行。9名（82%）儿童出现强迫症状，其中4名符合强迫症的诊断标准。这些行为症状在观察到舞蹈病前数天至数周开始出现，其严重程度随运动异常而波动。这些结果表明，心理症状，尤其是强迫症状，是 Sydenham 舞蹈病的伴随表现，可能需要医学关注。
