Kühr J, Frischer T, Karmaus W, Meinert R
Universitäts-Kinderklinik, Freiburg i. Br.
Pneumologie. 1993 Feb;47(2):82-3.
In the framework of an epidemiological study, the information by peak flow variability (PEFV) was compared to the history of asthma in a non-selected population of primary-school children (n = 1812). PEFV as assessed by twice daily recordings of PEF for a one week period (n = 1237) was calculated as average of daily amplitudes (AVAM: average amplitude mean) in the case of at least complete data for five days (n = 991). Elevated PEFV defined as AVAM > 12%, was cross-tabulated with the asthma history (self-administered questionnaire). The median (90%-confidence-interval) of AVAM is 6.3% (2.2-15.9%). In 11.2% (n = 111) of the population, AVAM > 12% occurred). The sensitivity of AVAM > 12% with regard to "doctor's diagnosed asthma" (n = 35) is 37%. Under exclusion of children with recurrent wheezy bronchitis a specificity for AVAM > 12% of 90% is found. Our data on primary-school children suggests that PEFV is a specific but only slightly sensitive measurement with regard to previously diagnosed bronchial asthma.
在一项流行病学研究框架内，将小学儿童非特定人群（n = 1812）中通过呼气峰值流量变异性（PEFV）获得的信息与哮喘病史进行了比较。对于为期一周每天两次记录呼气峰值流量（PEF）评估的PEFV（n = 1237），在至少有五天完整数据的情况下（n = 991），计算为每日振幅的平均值（AVAM：平均振幅均值）。将定义为AVAM > 12% 的升高的PEFV与哮喘病史（自行填写问卷）进行交叉制表。AVAM的中位数（90% 置信区间）为6.3%（2.2 - 15.9%）。在11.2%（n = 111）的人群中，出现了AVAM > 12% 的情况。AVAM > 12% 对于“医生诊断的哮喘”（n = 35）的敏感性为37%。在排除复发性喘息性支气管炎儿童后，发现AVAM > 12% 的特异性为90%。我们关于小学儿童的数据表明，就先前诊断的支气管哮喘而言，PEFV是一种特异性但敏感性仅略高的测量方法。
