Hemachudha T, Panpanich T, Phanuphak P, Manatsathit S, Wilde H
World Health Organization Collaborating Centre for Research on Rabies Pathogenesis and Prevention, Queen Saovabha Memorial Institute, Bangkok, Thailand.
Trans R Soc Trop Med Hyg. 1993 Jan-Feb;87(1):106-8. doi: 10.1016/0035-9203(93)90446-w.
Serum cytokines were compared by enzyme-linked immunosorbent assay among (i) 28 patients with rabies, (ii) 13 patients with non-fatal encephalitis due to other viruses, (iii) 16 patients with immune-mediated neurological diseases, and (iv) 15 patients with non-viral central nervous system infections and non-HTLV-I progressive spastic paraparesis. Levels of soluble interleukin 2 receptor (S-IL2R) were comparable in groups (i)-(iii). Fewer paralytic (1/6) than encephalitic (12/22) rabies patients had elevated S-IL2R. Only one patient with rabies and one with non-fatal viral encephalitis (group ii) had elevated S-CD8. Interleukin 6 (IL-6) was elevated in 5/22 rabies patients with encephalitis and in 0/6 paralytic rabies patients. Four individuals in groups (ii) and (iii) had elevated IL-6. Patterns of cytokine responses in group (iv) were similar to those in groups (i)-(iii). The results suggest defects in immune responsiveness in paralytic rabies.
（i）28例狂犬病患者；（ii）13例由其他病毒引起的非致命性脑炎患者；（iii）16例免疫介导的神经疾病患者；以及（iv）15例非病毒性中枢神经系统感染和非人类嗜T淋巴细胞病毒I型（HTLV-I）进行性痉挛性截瘫患者。可溶性白细胞介素2受体（S-IL2R）水平在（i）-（iii）组中相当。麻痹型狂犬病患者（1/6）中S-IL2R升高的人数少于脑炎型狂犬病患者（12/22）。只有1例狂犬病患者和1例非致命性病毒性脑炎患者（ii组）的S-CD8升高。白细胞介素6（IL-6）在5/22例脑炎型狂犬病患者中升高，而在6例麻痹型狂犬病患者中无升高。（ii）组和（iii）组中有4人IL-6升高。（iv）组的细胞因子反应模式与（i）-（iii）组相似。结果提示麻痹型狂犬病存在免疫反应缺陷。
