Heath A C, Martin N G
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Addict Behav. 1993 Jan-Feb;18(1):19-34. doi: 10.1016/0306-4603(93)90005-t.
We reanalyze data from the 1981 mailed questionnaire survey of the Australian twin register, to test for a genetic effect on smoking persistence (whether or not a smoker quits smoking). In the young cohort, aged 18-30 years, there are too few ex-smokers to permit resolution of genetic and non-genetic models. In the older cohort, we find a significant and substantial genetic effect on smoking persistence, accounting for 53% of the variance. This genetic effect on smoking persistence is independent of genetic effects on smoking initiation.
我们重新分析了1981年澳大利亚双胞胎登记处邮寄问卷调查的数据，以测试吸烟持续性（吸烟者是否戒烟）的遗传效应。在18 - 30岁的年轻队列中，前吸烟者数量过少，无法区分遗传模型和非遗传模型。在年龄较大的队列中，我们发现吸烟持续性存在显著且实质性的遗传效应，占方差的53%。这种对吸烟持续性的遗传效应独立于对吸烟起始的遗传效应。
