U.S. Department of Health and Human Services, Public Health Service, Altanta, Georgia 30333, USA.
Am Fam Physician. 1993 Apr;47(5):1159-66.
The effects of acute exposure to methylene chloride (dichloromethane) are due to its central nervous system depressant properties, which have resulted in fatalities. Manifestations of acute exposure include mental confusion, fatigue, lethargy, headache and chest pain. Metabolic conversion of methylene chloride to carbon monoxide may place persons with preexisting coronary artery disease at increased risk. Sequelae following chronic exposure are unknown, but data suggest serious long-term effects. The Environmental Protection Agency considers methylene chloride to be a probable human carcinogen.
急性接触二氯甲烷的影响归因于其具有的中枢神经系统抑制特性，这已导致多起死亡事件。急性接触的表现包括精神错乱、疲劳、嗜睡、头痛和胸痛。二氯甲烷代谢转化为一氧化碳可能会使已有冠状动脉疾病的人面临更高风险。长期接触后的后遗症尚不清楚，但数据表明存在严重的长期影响。美国环境保护局认为二氯甲烷可能是一种人类致癌物。
