Barrueco J L, Gazquez A, Redondo E, Regodón S
Medical Center San Pedro de Alcantara, Traumatology Service, Caceres, Spain.
Ann Anat. 1993 Feb;175(1):47-51. doi: 10.1016/s0940-9602(11)80237-2.
A structural, ultrastructural and morphometric study of the coxofemoral articular cartilage of 48 Wistar rats was carried out after daily intramuscular injections of 2.5 mg prednisolone. The animals were divided into four groups, members of which were killed 15, 30, 60 and 90 days respectively after the start of the experiment. A degenerative process developed in the experimental animals, which led progressively to the death of chondrocytes in the middle zone of the articular cartilage after 90 days. Structural, ultrastructural and morphometric alterations were observed, both in cells and in the cartilage matrix. These gave rise to superficial changes in the femoral head.
对48只Wistar大鼠每日进行2.5毫克泼尼松龙肌肉注射后，对其髋股关节软骨进行了结构、超微结构和形态计量学研究。将动物分为四组，分别在实验开始后的15、30、60和90天处死每组动物。实验动物出现了退行性过程，90天后导致关节软骨中间区的软骨细胞逐渐死亡。在细胞和软骨基质中均观察到结构、超微结构和形态计量学改变。这些改变导致股骨头出现表面变化。
