鸡血脑屏障的发育。用伊文思蓝和辣根过氧化物酶进行的研究。
The development of the blood-brain barrier in the chick. Studies with evans blue and horseradish peroxidase.
作者信息
Ribatti D, Nico B, Bertossi M
机构信息
Institute of Human Anatomy, Histology and General Embryology, University of Bari, Italy.
出版信息
Ann Anat. 1993 Feb;175(1):85-8. doi: 10.1016/s0940-9602(11)80247-5.
The development of the blood-brain barrier was microscopically examined in the optic tectum of the chick. The permeability of neural vessels to Evans blue and horseradish peroxidase decreases progressively during the period of incubation. Diffusion is massive on the 6th and 10th days of incubation and is reduced on the 14th day; on the 18th-21st day of incubation the vascular walls still allow Evans blue to diffuse but prevent extravasation of horseradish peroxidase completely. In one month old chickens the nervous substrate is free of both tracers.
在雏鸡的视顶盖中，对血脑屏障的发育进行了显微镜检查。在孵化期间，神经血管对伊文思蓝和辣根过氧化物酶的通透性逐渐降低。在孵化的第6天和第10天，扩散大量存在，而在第14天减少；在孵化的第18 - 21天，血管壁仍允许伊文思蓝扩散，但完全阻止辣根过氧化物酶外渗。在1月龄的鸡中，神经基质中没有这两种示踪剂。
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