婴儿气管插管后脂解反应缺乏。
Lack of lipolytic response in infants after endotracheal intubation.
作者信息
Marcus C, Selldén H, Rickardsson E, Lönnqvist P A, Brönnegård M, Arner P
机构信息
Department of Paediatrics, Huddinge University Hospital, Sweden.
出版信息
Arch Dis Child. 1993 Mar;68(3):402-4. doi: 10.1136/adc.68.3.402.
The sympathoadrenal response to endotracheal intubation was investigated in nine infants 2-4 months old and in eight adults 23-45 years old at the start of inguinal hernia operations. In both infants and adults, heart rate and diastolic blood pressure increased significantly immediately after intubation. In both groups, moreover, there was a mean (SD) reduction in microvascular blood flow in the abdominal skin (infants -21 (14)%, adults -14 (7)%) and in the adipose tissue (infants -7 (4)%, adults -5 (4)%). However, the plasma glycerol concentration did not increase in the infants whereas it increased in the adults by 50 (12)%. In conclusion, infants and adults showed similar circulatory reactions during endotracheal intubation but the markedly increased lipolysis rate observed in adults was not seen in the infants. This may indicate that catecholamine induced lipolysis in vivo as well as in vitro is poor during infancy.
在腹股沟疝手术开始时，对9名2至4个月大的婴儿和8名23至45岁的成年人进行了气管插管时交感肾上腺反应的研究。在婴儿和成年人中，插管后心率和舒张压均立即显著升高。此外，两组患者腹部皮肤的微血管血流量均出现平均（标准差）下降（婴儿组下降21（14）%，成人组下降14（7）%），脂肪组织中微血管血流量也下降（婴儿组下降7（4）%，成人组下降5（4）%）。然而，婴儿的血浆甘油浓度没有升高，而成年人的血浆甘油浓度升高了50（12）%。总之，婴儿和成年人在气管插管期间表现出相似的循环反应，但在婴儿中未观察到成年人中明显增加的脂肪分解率。这可能表明婴儿期体内外儿茶酚胺诱导的脂肪分解作用较差。
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