La Porta C A, Comolli R
Department of General Physiology and Biochemistry, University of Milan, Italy.
Biochem Biophys Res Commun. 1993 Mar 31;191(3):1124-30. doi: 10.1006/bbrc.1993.1333.
The PKC alpha, beta, delta, epsilon and zeta isoenzyme changes in the rat kidney cortex have been investigated after temporary occlusion of the renal artery, followed by reperfusion for up to 4 h. Increased PKC alpha, delta and epsilon immunoreactivity and PKC alpha activity occurred within 60 min of postischemic reflow, while PKC beta and zeta were unmodified. Increased PKC beta activity was present at later times of reflow (120 min), suggesting that the initial events of the regenerative repair response after an ischemic insult implicate the activation of specific PKC isoenzymes (alpha, delta, epsilon), playing a role in the control of cell proliferation.
在大鼠肾动脉暂时阻断并再灌注长达4小时后，对大鼠肾皮质中蛋白激酶C（PKC）α、β、δ、ε和ζ同工酶的变化进行了研究。缺血后再灌注60分钟内，PKCα、δ和ε的免疫反应性及PKCα活性增加，而PKCβ和ζ未发生改变。再灌注后期（120分钟）出现PKCβ活性增加，这表明缺血损伤后再生修复反应的初始事件涉及特定PKC同工酶（α、δ、ε）的激活，其在细胞增殖控制中发挥作用。
