Morita M, Folkers K
Institute for Biomedical Research, University of Texas, Austin 78712.
Biochem Biophys Res Commun. 1993 Mar 31;191(3):950-4. doi: 10.1006/bbrc.1993.1309.
This method has been designed to determine the levels of CoQ10 in human blood which utilizes only one drop of blood (0.05 ml). This method encourages and facilitates more frequent monitoring of blood levels of CoQ10, and of clinical importance, reveals the presence or absence of compliance. CoQ11 was used as an internal standard. The mean recovery of CoQ10 was 96%. The correlation coefficient between using 1.0 ml and 0.1 ml of blood and between using 1.0 and 0.05 ml was 0.997 in the two comparisons. Therefore, it can be accurate to monitor the level of CoQ10 in a -"finger-prick"-drop of blood, and at least 24 such determinations can be conducted in a 2-day period.
该方法旨在测定人血中辅酶Q10的水平，仅需一滴血（0.05毫升）。此方法有助于并促进更频繁地监测辅酶Q10的血药浓度，且具有临床意义的是，可显示是否依从。辅酶Q11用作内标。辅酶Q10的平均回收率为96%。在两次比较中，使用1.0毫升与0.1毫升血液以及使用1.0与0.05毫升血液之间的相关系数均为0.997。因此，用“指尖采血”的一滴血来监测辅酶Q10水平是准确的，并且在两天内至少可以进行24次这样的测定。
