Cohen J J
Dept of Microbiology and Immunology, University of Colorado Medical School, Denver 80262.
Immunol Today. 1993 Mar;14(3):126-30. doi: 10.1016/0167-5699(93)90214-6.
Cell death can be accidental or programmed in a multicellular organism. Evidence supports the proposition that there is a 'suicide program' inherent in vertebrate cells which can be activated when the cell's death is desirable for the good of the rest of the community. The morphology of such death is usually that of apoptosis, rather than of necrosis. Here, John Cohen describes the changes of apoptosis, and discusses progress on the identification of regulatory mechanisms and genes.
在多细胞生物中，细胞死亡可以是意外的，也可以是程序性的。有证据支持这样一种观点，即脊椎动物细胞中存在一种“自杀程序”，当细胞死亡对机体其他部分有益时，该程序可以被激活。这种死亡的形态通常是凋亡，而不是坏死。在此，约翰·科恩描述了凋亡的变化，并讨论了在识别调控机制和基因方面取得的进展。
