Cegielski J P, Msengi A E, Dukes C S, Mbise R, Redding-Lallinger R, Minjas J N, Wilson M L, Shao J, Durack D T
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
AIDS. 1993 Feb;7(2):213-21. doi: 10.1097/00002030-199302000-00009.
To determine whether specific intestinal parasites are associated with HIV infection in Tanzanian children with chronic diarrhea.
A prospective, cross-sectional study.
Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania.
All children aged 15 months to 5 years admitted with chronic diarrhea, and age-matched controls.
Standardized history, physical examination, HIV serology, and stool parasitology were evaluated for all subjects. We compared three groups: HIV-infected and non-HIV-infected children with chronic diarrhea and controls without diarrhea.
Fecal parasites and nutritional status.
Chronic diarrhea accounted for one-quarter of all cases of diarrheal disease in the defined age range, and children with chronic diarrhea were severely malnourished. Forty per cent of subjects with chronic diarrhea were HIV-seropositive. Although intestinal parasites were detected in approximately 50% of all three groups, diarrheagenic parasites were detected in up to 40% of children with chronic diarrhea. Blastocystis hominis was detected only in HIV-infected patients.
HIV infection was common in children with chronic diarrhea, and parasitic agents of diarrhea may be important in children with chronic diarrhea both with and without HIV infection in this setting. B. hominis was more frequent in HIV-infected children. The immunocompromising effects of severe malnutrition may have diminished the difference between HIV-infected and non-HIV-infected children.
确定坦桑尼亚慢性腹泻儿童中特定肠道寄生虫是否与艾滋病毒感染有关。
一项前瞻性横断面研究。
坦桑尼亚达累斯萨拉姆的穆希姆比利卫生科学大学学院。
所有15个月至5岁因慢性腹泻入院的儿童以及年龄匹配的对照组儿童。
对所有研究对象进行标准化病史、体格检查、艾滋病毒血清学和粪便寄生虫学评估。我们比较了三组：感染艾滋病毒和未感染艾滋病毒的慢性腹泻儿童以及无腹泻的对照组。
粪便寄生虫和营养状况。
在规定年龄范围内，慢性腹泻占所有腹泻病例的四分之一，慢性腹泻儿童严重营养不良。40%的慢性腹泻研究对象艾滋病毒血清呈阳性。尽管三组中约50%检测到肠道寄生虫，但高达40%的慢性腹泻儿童检测到致泻性寄生虫。人芽囊原虫仅在艾滋病毒感染患者中检测到。
艾滋病毒感染在慢性腹泻儿童中很常见，在这种情况下，腹泻的寄生虫病原体对于感染和未感染艾滋病毒的慢性腹泻儿童可能都很重要。人芽囊原虫在艾滋病毒感染儿童中更常见。严重营养不良的免疫抑制作用可能缩小了感染艾滋病毒和未感染艾滋病毒儿童之间的差异。
