Maharaj B, van der Byl K
Department of Experimental and Clinical Pharmacology, University of Natal Medical School, Durban, South Africa.
Am J Hypertens. 1993 Mar;6(3 Pt 2):80S-81S. doi: 10.1093/ajh/6.3.80s.
Fifty-two black men who had supine diastolic blood pressures (DBP) above 95 mm Hg at the end of a 2-week placebo wash-out period were randomized to receive either isradipine SRO at 2.5 mg/day or enalapril at 10 mg/day for 8 weeks. After 4 weeks, the dosages were doubled if DBP remained above 90 mm Hg. Reductions in blood pressure were comparable in both groups. Mean supine DBP was reduced from 100.6 to 93.9 mm Hg in the isradipine-treated group, and from 103.9 to 98.2 mm Hg in the enalapril-treated group. At the end of the study, 24/27 patients were taking 5 mg isradipine SRO once daily, and 20/25 patients were taking 20 mg enalapril once daily. There were no serious adverse events. The results of this study indicated that monotherapy with isradipine SRO at the recommended initial dosage of 5 mg once daily is appropriate in black patients with hypertension. This was, however, not the case with enalapril at 10 mg once daily. The concurrent administration of a diuretic with enalapril may be more appropriate.
52名黑人男性在经过2周的安慰剂洗脱期后，仰卧位舒张压（DBP）高于95 mmHg，他们被随机分为两组，一组每天服用2.5 mg伊拉地平缓释口服制剂（isradipine SRO），另一组每天服用10 mg依那普利，为期8周。4周后，如果DBP仍高于90 mmHg，则将剂量加倍。两组的血压下降情况相当。伊拉地平治疗组的平均仰卧位DBP从100.6 mmHg降至93.9 mmHg，依那普利治疗组从103.9 mmHg降至98.2 mmHg。研究结束时，24/27例患者每天服用一次5 mg伊拉地平缓释口服制剂，20/25例患者每天服用一次20 mg依那普利。未发生严重不良事件。该研究结果表明，对于高血压黑人患者，每天一次5 mg的推荐初始剂量伊拉地平缓释口服制剂单药治疗是合适的。然而，每天一次10 mg依那普利并非如此。依那普利与利尿剂联合使用可能更合适。
