Nakazawa M
Second Department of Surgery, Mie University School of Medicine, Tsu, Japan.
Surg Today. 1993;23(3):215-9. doi: 10.1007/BF00309230.
Flow cytometric DNA analysis was performed on 45 neuroblastomas in order to evaluate the prognostic significance of DNA ploidy. The DNA ploidy was diploid in 14 and aneuploid in 31 neuroblastomas and did not correlate with the conventional prognostic variables such as age, Evans' stage, or the primary site of the tumor. The survival of 31 patients with aneuploid tumors was comparable to that of 14 patients with diploid tumors. On the other hand, DNA aneuploidy was associated with a decreased long-term survival in 21 patients older than 24 months of age at the time of operation, and in 27 patients with advanced disease at Evans' stage III or IV. These results suggest that more intensive and longer-term postoperative chemotherapy is necessary for neuroblastoma patients older than 24 months of age, or for those with advanced disease if they have aneuploid tumors.
为了评估DNA倍性的预后意义，对45例神经母细胞瘤进行了流式细胞术DNA分析。14例神经母细胞瘤的DNA倍性为二倍体，31例为非整倍体，且与年龄、埃文斯分期或肿瘤原发部位等传统预后变量无关。31例非整倍体肿瘤患者的生存率与14例二倍体肿瘤患者相当。另一方面，DNA非整倍体与手术时年龄超过24个月的21例患者以及埃文斯分期为III或IV期的晚期疾病的27例患者的长期生存率降低有关。这些结果表明，年龄超过24个月的神经母细胞瘤患者或患有晚期疾病且肿瘤为非整倍体的患者需要更强化和更长期的术后化疗。
