视网膜母细胞瘤后除骨肉瘤外的骨肿瘤。
Bone tumors other than osteosarcoma after retinoblastoma.
作者信息
Helton K J, Fletcher B D, Kun L E, Jenkins J J, Pratt C B
机构信息
Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN 38101-0318.
出版信息
Cancer. 1993 May 1;71(9):2847-53. doi: 10.1002/1097-0142(19930501)71:9<2847::aid-cncr2820710928>3.0.co;2-e.
BACKGROUND
The most frequent second malignant neoplasm after retinoblastoma is osteosarcoma, which may be associated with radiation therapy or arise de novo in patients with bilateral retinoblastoma.
METHODS
Clinical, pathologic, and diagnostic imaging findings in two patients with Ewing sarcoma (ES) and one with peripheral neuroepithelioma (PN) are presented.
RESULTS
Second malignant neoplasms located in the extremities or pelvis were seen 12-18 years after initial diagnosis of unilateral (two patients) or bilateral (one patient) retinoblastoma. The patients with unilateral retinoblastoma were treated by enucleation only; the other received ocular radiation therapy and chemotherapy. To the knowledge of the authors, this is the first documentation of round blue cell tumor after unilateral retinoblastoma.
CONCLUSIONS
ES and PN should be included in the differential diagnosis of malignant neoplasms occurring after treatment of unilateral or bilateral retinoblastoma.
背景
视网膜母细胞瘤之后最常见的第二原发性恶性肿瘤是骨肉瘤，其可能与放射治疗相关，或在双侧视网膜母细胞瘤患者中自发出现。
方法
介绍了两名尤因肉瘤（ES）患者和一名外周原始神经外胚层瘤（PN）患者的临床、病理及诊断影像学表现。
结果
在单侧（两名患者）或双侧（一名患者）视网膜母细胞瘤初次诊断后12 - 18年，发现了位于四肢或骨盆的第二原发性恶性肿瘤。单侧视网膜母细胞瘤患者仅接受了眼球摘除术；另一名患者接受了眼部放射治疗和化疗。据作者所知，这是单侧视网膜母细胞瘤后出现圆形蓝细胞瘤的首次记录。
结论
ES和PN应纳入单侧或双侧视网膜母细胞瘤治疗后发生的恶性肿瘤的鉴别诊断。
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