Alexander B M, Van Kirk E A, Rose J D, Murdoch W J, Moss G E
Department of Animal Science, University of Wyoming, Laramie 82071.
Domest Anim Endocrinol. 1993 Jan;10(1):7-14. doi: 10.1016/0739-7240(93)90003-t.
Histamine has been implicated as a neuromodulator of secretion of gonadotropins in several species. Concentrations of histamine were analyzed within discrete brain regions and endocrine tissues to help determine whether this amine has the potential to exert a similar function in ewes expected to have dramatically different serum concentrations of LH. Following collection of blood samples at 12-min intervals for 4-hr, ovariectomized (OVX) and OVX-estradiol treated (OVX-E) ewes were slaughtered during the breeding and anestrous seasons (five animals/group). Concentrations of LH were depressed by treatment with estradiol (E; P < .01), but to a greater extent (P < .05) during the anestrous season compared to the breeding season. Concentrations of histamine in tissues (ng/mg) differed (P < .01) between the breeding and anestrous seasons, in the medial thalamus (39.2 +/- 14.1 vs 109.9 +/- 13.0), posterior pituitary gland (247.6 +/- 50.7 vs 23.0 +/- 9.1) and midbrain tegmentum (10.4 +/- 5.6 vs 50.7 +/- 3.9). Estradiol containing implants decreased (P < .05) concentrations of histamine in the midbrain tegmentum (20.3 +/- 7.1 vs 37.7 +/- 7.8) and posterior pituitary gland (87.3 +/- 24.0 vs 258.2 +2- 67.5) compared to non-estradiol treated controls. Histamine concentrations in the pineal and anterior pituitary glands and brain regions; stalk-median eminence, medial basal hypothalamus, preoptic area, cerebellum, parietal neocortex, were not (P > .05) affected solely by either season or E. An interaction between effects of season and estradiol on concentrations of histamine occurred (P < .05) in the posterior pituitary gland and the preoptic area.(ABSTRACT TRUNCATED AT 250 WORDS)
组胺已被认为是几种物种中促性腺激素分泌的神经调节剂。分析了离散脑区和内分泌组织中的组胺浓度，以帮助确定这种胺是否有可能在预期血清促黄体生成素（LH）浓度差异很大的母羊中发挥类似功能。在4小时内每隔12分钟采集一次血样后，在繁殖季节和发情间期宰杀去卵巢（OVX）和接受雌二醇处理的去卵巢（OVX-E）母羊（每组5只动物）。雌二醇（E）处理可降低LH浓度（P < 0.01），但与繁殖季节相比，发情间期降低的程度更大（P < 0.05）。繁殖季节和发情间期之间，内侧丘脑（39.2±14.1对109.9±13.0）、垂体后叶（247.6±50.7对23.0±9.1）和中脑被盖（10.4±5.6对50.7±3.9）组织中的组胺浓度存在差异（P < 0.01）。与未接受雌二醇处理的对照组相比，含雌二醇的植入物可降低中脑被盖（20.3±7.1对37.7±7.8）和垂体后叶（87.3±24.0对258.2±67.5）中的组胺浓度（P < 0.05）。松果体、垂体前叶以及脑区（视交叉上核-正中隆起、内侧基底下丘脑、视前区、小脑、顶叶新皮质）中的组胺浓度不受季节或E单独影响（P > 0.05）。垂体后叶和视前区出现了季节和雌二醇对组胺浓度影响的相互作用（P < 0.05）。（摘要截短至250字）
