碱性成纤维细胞生长因子的延迟给药可保护新生大鼠免受N-甲基-D-天冬氨酸的神经毒性作用。

Delayed administration of basic fibroblast growth factor protects against N-methyl-D-aspartate neurotoxicity in neonatal rats.

作者信息

Nozaki K, Finklestein S P, Beal M F

机构信息

Stroke Research, Massachusetts General Hospital, Boston 02114.

出版信息

Eur J Pharmacol. 1993 Mar 2;232(2-3):295-7. doi: 10.1016/0014-2999(93)90788-j.

DOI:10.1016/0014-2999(93)90788-j

PMID:8467865

Abstract

Neuroprotective effects of basic fibroblast growth factor (bFGF) (200 mu/kg i.p.) were examined at different time points following intrastriatal injection of N-methyl-D-aspartate (NMDA) in seven-day-old rats. When administered 0.5 h before intrastriatal NMDA injection, 200 micrograms/kg of bFGF significantly reduced NMDA-induced lesion by 47% as compared with vehicle treatment. Posttreatment with the same dose of bFGF at 0, 0.5 or 1 h after NMDA injection also significantly reduced those lesions by 45, 35 or 26%, respectively, while no neuroprotective effects was observed when administered at 2 or 4 h after NMDA injection.

摘要

在7日龄大鼠纹状体内注射N-甲基-D-天冬氨酸（NMDA）后的不同时间点，检测碱性成纤维细胞生长因子（bFGF，200μg/kg腹腔注射）的神经保护作用。在纹状体内注射NMDA前0.5小时给予200μg/kg的bFGF，与溶剂处理组相比，可使NMDA诱导的损伤显著减少47%。在NMDA注射后0、0.5或1小时用相同剂量的bFGF进行治疗，也分别使这些损伤显著减少45%、35%或26%，而在NMDA注射后2或4小时给予bFGF则未观察到神经保护作用。