The novel 5-HT4 receptor antagonist DAU 6285 antagonizes 5-hydroxytryptamine-induced tachycardia in pigs.

作者信息

Van Meel J C, Diederen W, Haigh R, Wienen W, Pairet M, Turconi M, Doods H N

机构信息

Department of Pharma Research, Dr. Karl Thomae GmbH, Biberach/Riss, Germany.

出版信息

Eur J Pharmacol. 1993 Mar 23;233(2-3):295-7. doi: 10.1016/0014-2999(93)90065-p.

The 5-HT4 receptor antagonist action of DAU 6285 was investigated in vivo in anesthetized pigs. DAU 6285 (0.3-3 mg/kg i.v.) dose dependently antagonized 5-hydroxytryptamine (5-HT)-induced tachycardiac responses. In contrast, the 5-HT3 receptor antagonist, ondansetron (0.3-3 mg/kg i.v.) did not influence the tachycardia induced by 5-HT. These results indicate that DAU 6285 is a potent antagonist of 5-HT4 receptor-mediated responses in vivo.