Carstens C, Niethard F U
Abteilung für Orthopädie im Kindesalter, Stiftung Orthopädische Universitätsklinik Heidelberg.
Geburtshilfe Frauenheilkd. 1993 Mar;53(3):182-5. doi: 10.1055/s-2007-1023661.
Questionnaires were sent to 1000 parents of children with myelomeningocele in order to get a better knowledge of the present state of prenatal diagnosis of this disease. 566 parents answered; 488 responders, in whom the pregnancy took place 1982 and later, were evaluated in detail. 85% of the parents reported having been checked by ultrasound 2 times and more during pregnancy: however, only 27% of the myelomeningoceles were detected before delivery. 83% were diagnosed between the 30th and 40th week of pregnancy. The rate of discovery rose from 0% and 37% between 1982 and 1990. As a consequence of this result, one should make every effort by using ultrasound and alpha-foetoprotein-screening to verify or to exclude a myelomeningocele in an early phase of pregnancy. The delivery should take place in a specialised centre, and the knowledge of life expectancy and life quality of these patients should be improved, for the obstetricians as well as for the parents.
为了更好地了解脊髓脊膜膨出症的产前诊断现状,我们向1000名患有脊髓脊膜膨出症患儿的家长发放了调查问卷。566名家长进行了回复;其中488名在1982年及以后怀孕的回复者接受了详细评估。85%的家长报告在孕期接受过2次及以上超声检查:然而,只有27%的脊髓脊膜膨出症在分娩前被检测出来。83%是在怀孕第30至40周之间被诊断出来的。1982年至1990年间,发现率从0%上升到37%。鉴于这一结果,应尽一切努力通过超声检查和甲胎蛋白筛查,在怀孕早期核实或排除脊髓脊膜膨出症。分娩应在专业中心进行,并且对于产科医生和家长而言,应提高对这些患者预期寿命和生活质量的认识。