Yamashita H, Yamamoto M, Sato Y, Izawa T, Komabayashi T, Saito D, Ohno H
Department of Hygiene, National Defense Medical College, Tokorozawa, Japan.
Int J Biometeorol. 1993 Feb;37(1):61-4. doi: 10.1007/BF01212769.
The effect was investigated of endurance training on the expression of uncoupling protein (UCP) mRNA in brown adipose tissue (BAT) of rats. The exercised rats were trained on a rodent treadmill for 5 days per week and a total of 9 weeks. After the training programme, a marked decrease in BAT mass was found in terms of weight or weight per unit body weight; there was a corresponding decrease in DNA content and a downward trend in RNA and glycogen levels. The UCP mRNA was present at a markedly decreased level in BAT of trained animals. In consideration of the reduced levels of mRNAs for hormone-sensitive lipase and acyl-CoA synthetase, the brown adipose tissue investigated appeared to be in a relatively atrophied and thermogenically quiescent state.
研究了耐力训练对大鼠棕色脂肪组织（BAT）中解偶联蛋白（UCP）mRNA表达的影响。运动大鼠每周在啮齿动物跑步机上训练5天，共训练9周。训练计划结束后，发现BAT重量或单位体重的重量显著下降；DNA含量相应减少，RNA和糖原水平呈下降趋势。训练动物的BAT中UCP mRNA水平显著降低。考虑到激素敏感性脂肪酶和酰基辅酶A合成酶的mRNA水平降低，所研究的棕色脂肪组织似乎处于相对萎缩和产热静止状态。
