Woggon B
Psychiatrische Universitätsklinik Zürich, Switzerland.
Int Clin Psychopharmacol. 1993 Jan;7(3-4):137-9. doi: 10.1097/00004850-199300730-00003.
Earlier studies demonstrated that moclobemide has good efficacy as an antidepressant. Its efficacy was comparable to reference antidepressants, both in endogenous and non-endogenous depression. A meta-analysis was performed of recent data from more than 2000 patients who had participated in double-blind trials with moclobemide and comparison drugs. Based on HAMD-17 baseline scores, the sample was divided into three groups according to the severity of depression. In all three, moclobemide was as effective as comparison drugs, both in endogenous and non-endogenous depression. The antidepressant efficacy of both moclobemide and reference drugs was more pronounced in endogenous than in non-endogenous depression, whatever the severity.
早期研究表明，吗氯贝胺作为一种抗抑郁药具有良好的疗效。在内源性和非内源性抑郁症中，其疗效与参比抗抑郁药相当。对2000多名参与吗氯贝胺与对照药物双盲试验的患者的近期数据进行了荟萃分析。根据汉密尔顿抑郁量表-17基线评分，将样本按抑郁严重程度分为三组。在所有这三组中，在内源性和非内源性抑郁症中，吗氯贝胺与对照药物的效果一样好。无论严重程度如何，吗氯贝胺和参比药物的抗抑郁疗效在内源性抑郁症中比在非内源性抑郁症中更显著。
