Brooks D J
MRC Cyclotron Unit, Hammersmith Hospital, London, UK.
J Neurol Sci. 1993 Mar;115(1):1-17. doi: 10.1016/0022-510x(93)90061-3.
Parkinsonism is a feature not only of Parkinson's disease but also of many other diseases affecting basal ganglia function. Functional imaging (PET and SPECT) can demonstrate the various resting patterns of disruption of regional cerebral blood flow, metabolism, and neuropharmacology associated with different parkinsonian disorders. 18F-dopa PET also has the potential to detect subclinical dysfunction of dopaminergic terminals in at-risk subjects. Finally, functional imaging can help us understand the nature of the networks involved in performing different motor tasks, and can reveal how these networks malfunction in the presence of bradykinesia or parkinsonian tremor.
帕金森综合征不仅是帕金森病的特征，也是许多其他影响基底神经节功能的疾病的特征。功能成像（正电子发射断层扫描和单光子发射计算机断层扫描）可以显示与不同帕金森病相关的区域脑血流、代谢和神经药理学破坏的各种静息模式。18F-多巴正电子发射断层扫描也有潜力检测高危受试者多巴胺能终末的亚临床功能障碍。最后，功能成像可以帮助我们理解执行不同运动任务所涉及的网络的性质，并可以揭示在运动迟缓或帕金森震颤存在时这些网络是如何发生故障的。
