Andersson M A, Bergström T B, Blomstrand C, Hermodsson S H, Håkansson C, Löwhagen G B
Department of Neurology, University of Gothenburg, Sahlgren's Hospital, Sweden.
J Neuroimmunol. 1988 Oct;19(4):291-304. doi: 10.1016/0165-5728(88)90010-0.
Cerebrospinal fluid from 34 human immunodeficiency virus (HIV-1) seropositive patients, only four of whom had HIV-related neurological symptoms, was examined by cytology, protein quantification, isoelectric focusing and specific serological tests. CSF lymphocytosis and evidence of intrathecal IgG production, found in 21 and 20 respectively of the 34 patients, correlated significantly with the duration of the infection. Increasing IgG index was found in two patients with repeated CSF examinations during greater than 7 years. Intrathecal HIV antibodies were detected on Western blot in 32/34 patients. HIV antigen test positive in 5/34 sera was negative in all 34 CSF samples. Intrathecal B cell activation seems to increase during the early HIV infection.
对34例人类免疫缺陷病毒（HIV-1）血清学阳性患者的脑脊液进行了细胞学、蛋白质定量、等电聚焦和特异性血清学检测，其中只有4例有HIV相关神经系统症状。在34例患者中，分别有21例和20例出现脑脊液淋巴细胞增多和鞘内IgG产生的证据，这与感染持续时间显著相关。在超过7年的时间里，对2例患者进行了多次脑脊液检查，发现IgG指数升高。在34例患者中的32例通过蛋白质印迹法检测到鞘内HIV抗体。34份血清中有5份HIV抗原检测呈阳性，但所有34份脑脊液样本检测均为阴性。在HIV感染早期，鞘内B细胞活化似乎会增加。
