Bokor M, Faragó A, Garam T, Malatinszky G, Schnabel R
Department of Neurology, Municipal Nyírö Gyula Hospital, Budapest, Hungary.
J Neurol Sci. 1993 Mar;115(1):47-50. doi: 10.1016/0022-510x(93)90065-7.
The possible role of a non-specific cell-mediated immune reaction in the pathogenesis of Parkinson's disease (PD) is discussed. It was found that the killer cell activity of PD patients below 60 years of age was significantly lower than in the older age groups or in the age-matched control group. On the other hand, it was also found that the killer cell activity of PD patients with severe symptoms (Hoehn-Yahr's IV, V stage) was significantly higher than that of the milder cases. These results support the hypothesis that an ADCC reaction--mediated by the killer cells--may play a role in the pathogenesis of PD.
本文讨论了非特异性细胞介导免疫反应在帕金森病（PD）发病机制中的可能作用。研究发现，60岁以下PD患者的杀伤细胞活性显著低于老年组或年龄匹配的对照组。另一方面，还发现症状严重（ Hoehn-Yahr分级IV、V期）的PD患者的杀伤细胞活性明显高于症状较轻的患者。这些结果支持了由杀伤细胞介导的抗体依赖细胞介导的细胞毒性反应（ADCC反应）可能在PD发病机制中起作用这一假说。
