Bokor M, Faragó A, Schnabel R, Garam T
Department of Neurology, Municipal Nyírö Gyula Hospital, Budapest.
Ther Hung. 1992;40(2):51-7.
Considering the eventual role of non-specific cell-mediated immune reactions in the pathogenesis of Parkinson's syndrome based on the destruction of dopaminergic cells of the substantia nigra the killer cell activity of patients suffering from this disease has been examined. According to the results the killer cell activity of Parkinson patients is significantly lower in the age group below 60 years as compared to the higher age groups. When comparing the age groups below 60 years, significantly lower activity was measured in the patients than in the controls. Killer cell activity is significantly higher in patients suffering from more severe conditions (Hoehn-Yahr's stage IV-V) when compared to the milder cases. These results suggest the possibility that killer cell-mediated ADCC reaction may play a role in the pathogenesis of the disease. The results of these examinations open new therapeutic perspectives. It may be hoped that, as a result of our increasing knowledge and technical progress in immunology, the damaged immune system could be selectively influenced and target specific immune therapy could be used in the near future by means of for instance inactivations of cytotoxic cells, elimination of antibodies or other immunological methods.
基于黑质多巴胺能细胞的破坏，考虑到非特异性细胞介导的免疫反应在帕金森综合征发病机制中的最终作用，对患有这种疾病的患者的杀伤细胞活性进行了检测。结果显示，60岁以下年龄组的帕金森病患者的杀伤细胞活性明显低于年龄较大的组。在比较60岁以下的年龄组时，患者的活性明显低于对照组。与病情较轻的患者相比，病情较重（霍恩-雅尔分期IV-V期）的患者的杀伤细胞活性明显更高。这些结果表明，杀伤细胞介导的ADCC反应可能在该疾病的发病机制中起作用。这些检查结果开辟了新的治疗前景。人们希望，随着我们在免疫学方面知识的不断增加和技术的进步，受损的免疫系统能够受到选择性影响，并且在不久的将来可以通过例如使细胞毒性细胞失活、消除抗体或其他免疫学方法来使用靶向特异性免疫疗法。
