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带造口的肝门空肠吻合术对接受原位肝移植的小儿胆道闭锁患者发病率的影响。

The influence of portoenterostomy with stoma on morbidity in pediatric patients with biliary atresia undergoing orthotopic liver transplantation.

作者信息

Meister R K, Esquivel C O, Cox K L, Concepcion W, Berquist W, Nakazato P, deVries P A

机构信息

Department of Transplantation, California Pacific Medical Center, San Francisco.

出版信息

J Pediatr Surg. 1993 Mar;28(3):387-90. doi: 10.1016/0022-3468(93)90237-f.

Abstract

A portoenterostomy (PE) procedure for extrahepatic biliary atresia (EHBA) is sometimes performed with a stoma in an attempt to reduce the incidence of acute cholangitis. The purpose of this study was to determine if the presence of a stoma increased the complication rate of patients undergoing orthotopic liver transplantation (OLT) for EHBA. The medical records of 42 consecutive patients with EHBA who underwent primary OLT between October 1988 and October 1991 were retrospectively reviewed. Three patients were excluded, since their grafts were lost within 3 days of OLT. The remaining 39 patients were divided into three groups: no PE (n = 7), PE without stoma (n = 23), and PE with stoma (n = 9). The mean age of the whole group was 19.62 +/- 24.37 months, with a range of 5 to 132 months. Mean weight was 9.62 kg, with a range of 4.2 to 41 kg. Survival at 3 and 12 months as well as number of retransplantations were similar among the three groups. However, at the time of OLT increased morbidity was observed, consisting of increased operative time and number of reoperations, whether or not the stoma had been closed prior to OLT.

摘要

对于肝外胆管闭锁(EHBA),有时会施行带有造口的肝门空肠吻合术(PE),以试图降低急性胆管炎的发生率。本研究的目的是确定造口的存在是否会增加接受原位肝移植(OLT)治疗EHBA患者的并发症发生率。回顾性分析了1988年10月至1991年10月期间连续42例接受初次OLT治疗的EHBA患者的病历。3例患者被排除,因为他们的移植物在OLT后3天内丢失。其余39例患者分为三组:未行PE(n = 7)、行PE但无造口(n = 23)和行PE且有造口(n = 9)。整个组的平均年龄为19.62 +/- 24.37个月,范围为5至132个月。平均体重为9.62 kg,范围为4.2至41 kg。三组患者在3个月和12个月时的生存率以及再次移植的次数相似。然而,在OLT时,无论造口在OLT前是否已关闭,均观察到发病率增加,包括手术时间延长和再次手术次数增加。

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